Sentence examples for binding in the brain from inspiring English sources

In conclusion, LP but not HF offspring show significantly elevated MOR and D1R binding in the brain thus affecting DA and opioid signaling.

Left: Transversal images of PDE10A binding in the brain.

Left: Transversal images of D2 receptor binding in the brain.

Figure 3 Quantitation of [ 18 F]flutemetamol binding in the brain of mouse models of AD.

A common assumption in studies with [11C](R -PK11195 is that the R -PK11195d has no specisic binding in thatbrain in vivo athehysiological conditions.

Although brain uptake was low, we wondered whether kinetic analysis of the brain and plasma data would suggest any specific binding in the brain.

The amyloid ligand H-PIB was also used to quantify brain amyloid levels, and the profiles for H-PIB autoradiography binding in the brains of 6- to 24-month-old APPswe mice and 8- to 24-month-old wt mice are displayed in Fig.  4a.

Our inability to detect the role of the α1D-receptor may be explainable by the fact that no one has yet succeeded in demonstrating any α1D-binding in the brain of either the rat (Yang et al, 1997), mouse (Yang et al, 1998), or rabbit (Piao et al, 2000) using the above antagonists as displacing agents.

We identify methyl-CpG binding protein 2 (MeCP2) as the major 5hmC binding protein in the brain, and demonstrate that MeCP2 binds 5hmC and 5mC containing DNA with similar high affinities.

Finally, with regard to binding potential in the brain, we assumed that equilibrium or near-equilibrium binding conditions existed in the brain at the time of peak brain uptake.

Several factors may have contributed to these results: (1) efflux transporters at the blood brain barrier, (2) low receptor density in humans, (3) lower in vivo binding affinity compared to that measured in vitro, (4) low delivery of the radioligand to brain, and (5) low binding potential in the brain.