Therefore, we performed DNA-protein binding arrays in the bone marrow of mice with metabolic syndrome, in blood-derived progenitor cells of diabetic patients as well as in VPC ex vivo treated with high levels of glucose.
For example, miR-21 was highly expressed in breast tumors [ 37] and a risk variant of a miR-125b binding site in the bone morphogenetic protein receptor type IB gene (BMPR1B) was also associated with breast cancer pathogenesis [ 38, 39].
Physiologically, OPN and ON are extra-cellular calcium-binding glycoproteins, which participate in the bone mineralisation via hydroxyapatite binding.
This ratio has been considered to be close to 1 for radionuclide therapy using peptides, assuming low or no specific binding of the radionuclide in the bone marrow [20], which was confirmed in a study with 177Lu-DOTATATE in which bone marrow and blood samples collected at the same time points were analysed [16].
Osteonectin (ON), also known as secreted protein, acidic, cysteine-rich (SPARC), is a calcium-dependent collagen binding protein particularly abundant in the bone.
The BAG-S53P4 composition (SiO2, Na2O, CaO, P2O5) facilitates tissue growth by binding chemically the bone matrix and thereby promote the formation of new bone in the implanted area.
Bisphosphonates target the underlying cause of skeletal morbidity by binding to the bone surface and inhibiting osteoclast-mediated bone resorption.
We hypothesized that the uptake 'plateau' of SUV 1 to 1.5 for both tracers consisted of both nonspecific binding as well as specific binding to VMAT2 expressed by cells in the bone marrow [25], while the gradual accumulation was due to irreversible [18F]F- binding to apatite in the cortical bone.
The binding of AGAb to cells in the bone marrow is very rapid and extensive because of the high concentration of granulocytes, promyelocytes and myelocytes that all express the NCA-95 antigen [ 33].
The cellular effects of OPN and BSP are transduced through their binding to a number of partners in the bone matrix and on cell surfaces, often via their RGD domains (Alford and Hankenson, 2006).
