Sentence examples for binding in the age from inspiring English sources

These ideas have been already included in modern models that look at ligand binding in the "age of dimers" as we should acknowledge [140, 141].

The −429 T/C and −374 T/A polymorphisms have been shown to exert significant effects on the transcriptional activity [ 13], and the G82S polymorphism, which occurs in the AGE binding domain, has been shown to have an enhanced ligand-binding affinity and leads to the increased ligand-stimulated activation of proinflammatory mediators [ 14].

The authors convincingly show that a specific pattern of atrophy is related to PD, aging, dopamine binding in the striatum, and UPDRS score.

AGE-BSA/RAGE binding in the cells was determined as described previously [ 23].

Figure 8A illustrates the low number of H-nicotine binding sites (α4β2 neuronal nicotinic acetylcholine receptors) especially in cortical regions (frontal, parietal and temporal) of the Alzheimer's disease brain in comparison with the regional H-nicotine binding in an age-matched control group (historical data from our research laboratory).

This demonstration of principle type of study was still able to show clear increasing trend in [ 18 F]flutemetamol binding in aging APP23 mice and the lack of binding in Tg2576 and APPswe-PS1dE9 mice.

Moreover, because the binding of AGEs to RAGE results in depletion of cellular antioxidant defense mechanisms and the generation of oxygen-free radicals (Schmidt et al. 1994), oxidant damage to myofibrillar proteins may play a role in the age-related reduction of contractile capacity (Thompson 2009).

After all, Chinese foot binding involved small girls, under the age of 9, having the bones in their feet repeatedly broken and then tightly bound in cloth, to control their shape: to make them as tiny as possible.

This scales the binding fraction based on the age-dependent levels of the binding protein (albumin) in blood.

Similarly, a study comparing PIB binding in early and late age-of-onset AD found that differences in cognitive profiles (more global deficits in early-onset AD, and restricted amnesia in late-onset AD) could not be explained by the distribution or burden of PIB, which was identical in the two groups [ 45].

The mild age-related symmetric reduction in DaT binding with increased age would therefore probably not have a significant effect on diagnostic performance of this test, and the findings in our study are in keeping with this hypothesis.