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Folding of cofactor-binding proteins involves ligand binding in addition to polypeptide folding.
Highly favorable, predominantly hydrophobic interactions between the sulfonamide scaffold and the hCA II active site were responsible for the binding, in addition to the coordination of the sulfamoyl moiety to the zinc ion.
The fact that ComE1 from P. multocida has sequence homology to ComEA DNA-binding proteins led to the hypothesis that this protein could have a role in DNA binding in addition to Fn binding.
Several distinct events can occur following Wnt-Frizzled receptor binding, in addition to β-catenin stabilisation.
This suggested that RNA binding in addition to aggregation is a component of TDP-43 toxicity (Fig. 1) (121).
Exploration of these variations could shed light on the biology of DNA binding in addition to improving prediction results.
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The VP domain also had slight DNA-binding in addition to the non-specific binding.
Notably, Alb/58, a human-adapted and high passage virus, seemingly possesses α2,3 glycan-binding, in addition to α2,6 SA binding; this double binding feature has previously been noted for H2N2 viruses [20].
The protein has a K-63 ubiquitin binding domain in addition to an LC3-binding domain, thus it appears to have a role in recruiting autophagosomes to mitochondria [116].
Another Middle gene, AS 1164, contains the Peritrophin-A chitin binding domain in addition to a prenyl-group binding site (InterPro ID IPR001230: CAAX box).
R306 therefore has an influence on DNA binding itself in addition to its role in NCoR complex binding, and having a defective C-terminus (R306C) is worse than having no C-terminus at all.
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