Sentence examples for binding impacts on the from inspiring English sources

These structures give the first insight into how nucleotide binding impacts on the overall structure of RH and demonstrates the potential use of this region as a novel drug target.

Our data reveal the nature of regulatory elements driving differential gene expression and inform how transcription factor binding impacts on promoter activity.

Because both Lys and Arg are basic amino acids, such substitutions are not expected to have dramatic impacts on the binding between the DBDs and their cognate binding sites.

Therefore, in this paper we used the Wien effect to evaluate the co-adsorption impacts on the binding energies of Cd2+ and Zn2+ retained on soil clay fractions.

How the free ligand's conformational envelope changes upon binding to its target to adopt the bound (bioactive) conformational envelope vitally impacts on the observed binding affinity.

The ligands bind to albumin either weakly or strongly and the type of binding will have impact on the distribution of these ligands as weakly bound ligands will have poor distribution and fast elimination and the strongly bound ligands will decrease the free ligand amount in plasma.

In summary, we present a novel tau modification occurring preferentially on 4-repeat tau protein which modifies microtubule-binding and may impact on the pathogenesis of tauopathies.

Mutations at I116H, I117P, P118S and W122G resulted in complete loss of AVFluIgG01 binding; moreover, mutations at S120N and S121A resulted in substantially reduced binding of AVFluIgG01, but had no impact on the binding of the polyclonal patient's serum (Table 6).

Using a saturation binding protocol, we found that MTα suppressed the maximum binding without any greater impact on the affinity of the radioligand, indicating a non-competitive mode of inhibition.

Moreover, we were able to demonstrate that both Smad and Klf4 binding have a regulatory impact on the CR3 region, see the next section.

We determined the crystal structure of GTP-bound L129F mutant Rab7 at 2.8 Å resolution revealing an alteration to the nucleotide binding pocket, but no impact on the catalytic region of Rab7.