Lower dopamine transporter binding has been associated with decreased initiative [ 55], whereas lower cholinergic receptor binding in the left frontal cortex has been reported to be associated with motor and mood changes of apathy [ 56].
It has previously been reported that the human MDR1 promoter contains an AP-1-binding site [ 38], and increased AP-1 binding [ 39] has been observed in several multidrug-resistant cell lines whereas reduced AP-1 binding has been associated with increased drug sensitivity in others [ 11, 40].
Ethylene binding has been associated with controlling the rate of ethylene receptor turnover in tomato [ 11], and in the case of non-climacteric fruit, the basal level of ethylene may be needed to sustain a certain receptor level and hence maintain ethylene perception for normal ripening to proceed.
Also, other properties such as lipid binding that have been associated with allergenicity can be explored [17], [18].
PfEMP1 variants mediate adhesion of IEs to different host endothelial receptors, and different binding properties have been associated with distinct patterns of sequestration and pathogenesis [8].
Odorant binding proteins have been associated to host defense and there is evidence that they play a role in resistance to B. thuringiensis intoxication in T. castaneum [ 16].
As a result, similar ERE binding properties have been associated with a partially distinct spectrum of ligands for each receptor, although with similar affinities for estrogen.
Besides the sequences classified as "response to stress" class according to GO terms, there are some other ESTs included in other categories such as "enzyme", "transporter" and "binding" that have been associated to biotic and/or abiotic stress in previous studies [ 27- 32].
As reviewed in (Kapeli & Yeo 2012), RNA-binding proteins have been associated with several neurological disorders.
TP53 mutations within the DNA-binding domain have been associated with poor treatment response and shorter survival in solid tumors.
