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Exact(9)
The effect that IA-HA has on MMPs, specifically MMP-13, through CD44 binding has been suggested to inhibit the effects of OA within the subchondral bone in numerous non-clinical basic science investigations [ 32, 45, 116– 116].
The analysis of the thermodynamic driving forces of ligand-protein binding has been suggested to be a key component for the selection and optimization of active compounds into drug candidates.
Variation in GAG binding has been suggested to co-determine cell type specificity [ 45].
Cp and MPO binding has been suggested to be related to an electrostatic interaction between the cationic nature of MPO and the anionic charges of Cp [ 17].
Strong aglycone binding has been suggested to be important for β-mannanases to be able to transglycosylate (Larsson et al. 2006; Rosengren et al. 2012).
Recently, Id-1 (inhibitor of differentiation or DNA binding) has been suggested as one of the upstream regulators of the EGFR pathway (Ling et al, 2004).
Similar(51)
Thus, only mechanisms for interfering with ATP binding have been suggested, while the residues that specifically recognize PPi remain unclear.
A similar binding site has been suggested in Synechocystis [ 32].
Genes coding for titin binding proteins has been suggested to act as members of a titin filament based stress sensing mechanoptotic machinery in previous mouse work [ 3].
Since these isoforms lack proper ligand binding, it has been suggested that these variants might interfere with the activity of the full-length NOD1 [ 11].
The 2G12 binding epitope has been suggested to include a noncontiguous patch of glycans on the "silent face" of gp120, i.e., the face opposite the site where mutational data and modeling results suggest that the peptide binds.
More suggestions(15)
settings has been suggested
binding has been shown
binding has been elucidated
binding has been developed
binding has been investigated
binding has been linked
binding has been determined
binding has been considered
binding has been evaluated
binding has been assigned
binding has been predicted
binding has been examined
binding has been identified
binding has been found
binding has been overlooked
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