Sentence examples for binding has been demonstrated from inspiring English sources
Cross-species binding has been demonstrated (i.e., mPD-1 can bind to hPD-L1, and hPD-1 can bind to mPD-L1), and the cross-species binding affinities show no significant differences compared to the intra-species interactions (Freeman et al., 2000; Latchman et al., 2001a, b; Zhang et al., 2004; Nomi et al., 2007; Cheng et al., 2013).
The ideal, biologically sound definition of a functional binding event is that the TF has been shown to bind at the site on a gene's promoter, and this binding has been demonstrated experimentally to affect the level of transcription of the gene.
Two molecules of AdoMet binding has been demonstrated in the case of PvuII MTase [46], T4 Dam MTase [47] and EcoDam MTase [48].
Loss of flexibility of disordered regions upon substrate binding has been demonstrated for the chaperones GroEL and α-crystallin.
In vivo FoxA1 binding has been demonstrated to correlate with H3K4 mono and dimethylation of enhancer elements [ 64].
No method or algorithm based on sequence data alone can predict regulatory function of individual transcription factor binding sites, even if binding has been demonstrated in vivo.
It has been shown that the LEPR Gln223Arg polymorphism is associated with variation in ligand binding; higher levels of ligand binding activity has been demonstrated in individuals homozygous for the G (LEPR Arg223Arg) allele than for carriers of the A (LEPR 223Gln) allele [ 16].
Progesterone binding activity has been demonstrated in nuclei purified from the adrenal cortex of guinea pigs, but the binding protein was considered distinct from classical PR, partly since a monoclonal antibody known to recognise guinea pig classical nuclear uterine PR failed to identify the protein [ 10].
When we sought to investigate its subcellular distribution, we hypothesized a similarity with ER beta localization in caveolar structures of platelets plasmamembrane, a binding which has been demonstrated important for its intracellular signalling [39].
Interestingly, docking of PTEN inhibitors to the tartrate binding site has been demonstrated after the removal of the C2 domain.
Elevated NF-κB DNA binding activity has been demonstrated both in breast cancer cell lines and primary breast cancer tissues [ 37, 38].
