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Native ECM possesses appropriate mechanical properties for physiological function of the biomaterial and signals for cell binding, growth and differentiation.
Glycosaminoglycans (GAG) are components from the extracellular matrix (ECM) that are able to interact and potentiate heparin binding growth factor (HBGF) activities.
This study suggests that heparin binding growth factors may be able to enhance vascular healing and remodeling of heparin bound biological grafts.
For example, among surface nucleolin binding growth factors: midkine and PTN can transform cells, whereas on endothelial cells they exert both mitogenic and angiogenic effect [17].
Indeed, HGF is a heparin binding growth factor.
Midkine, a heparin binding growth factor is a ligand of α4β1- and α6β1-integrins [ 99].
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In principle, HELP gel can bind any heparin-binding growth factor; we use fibroblast growth factor-2 (FGF2) in this study to demonstrate its utility.
The design of bioactivity is based on the potential ability to bind and slowly release heparin-binding growth factors.
Midkine (MK) is a heparin-binding growth factor that is overexpressed in various human cancers.
Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells.
RGTA® improves tissue healing in several animal models, by stabilizing and protecting heparin-binding growth factors (HBGFs) and matrix proteins.
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