Your English writing platform
Discover LudwigSuggestions(2)
Exact(1)
Analysis of the sequence and structure of the BH3 binding grooves showed that, despite low sequence identity, M11 has structural similarities to Bcl-xL, Bcl-2, and Bcl-w.
Similar(59)
In the spectra, peaks for G2267, G2270, and S2279 that occupy the top and bottom of the "CD" ligand binding groove showed changes that are typical of high-affinity binders.
Both classes of HLAs have a long binding groove that can bind peptides degraded from antigens.
Electrostatic potential calculated for the final stage of the DNA binding process shows that the DNA backbone is properly positioned against the positively charged regions of the protein with the DNA major/minor grooves positioned against the negatively charged regions of the DNA-binding groove along the entire DNA molecule (Figure 5B).
This suggests that there are probably other substitutions in the PRCP binding groove that restrict the carboxy-terminal peptide length.
These exons determine the amino acid residues of the peptide binding groove that is important for antigen presentation.
Computational modeling and DNA binding experiments have shown that the GT dinucleotide, which is common to both the ETS and CRE motifs, is bound by the CREB1 dimer in the major groove, and that GABPα binds in the minor groove, without protein protein interactions between the two proteins (Chatterjee et al. 2011).
Simultaneously, as shown in Fig. 6, the binding space of TP5 and its alanine substitutions in binding grooves was larger than that of the longer peptides.
(E ) Solvent occluded surface showing the two possible peptide-binding grooves that flank the peptide β-strand element (red).
Three arginines in the MutLLN40 DNA-binding groove are shown as red spheres.
These data showed that HL binding with a minor groove of DNA was the most stable.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com