Sentence examples for binding groove while the from inspiring English sources

The leucine and valine residues insert into the binding groove while the first residue, asparagine, tethers the peptide via an interaction with CPE's aspartate 225 and the two prolines are required to maintain the tight turn conformation.

The A and B domains form the substrate binding groove and contain the catalytic residues.

We find that Gd@C82(Ohas2 han an intrinsic binding preference to the binding groove, particularly the key signature residues Y28 and W39.

The α/β core subdomain of SHR forms the BIRD binding groove, which specifically recognizes the zinc fingers of JKD.

Ligands were docked into the canonical peptide binding groove of NHERF1 PDZ1, including the GYGF loop.

In addition, BbpSer547 Gln561 in the N3 domain moved toward the binding groove to make contact directly with the peptide, while BbpAsp338 Gly355 and BbpThr365 Tyr387 in N2 domain shifted their configurations to stabilize the reorganized C-terminus mainly through strong hydrogen bonds.

These findings indicate that the binding groove is hindered or occupied in the multi-motif proteins.

The open binding groove of MHC-II molecules can bind peptides of variable sizes.

Peptide sequence- and allele-dependent interactions along the entire length of the Ag binding groove influenced DM susceptibility.

This suggested that the center region of the peptide binding groove has increased flexibility.

HLA II binding peptides have an extended conformation at the binding groove unlike class I.