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A PA14 sequence alignment suggests a binding function, rather than a catalytic role, whereas the PA14 domain distribution is compatible with carbohydrate binding.
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However, it seems more likely that binding of the third Ca2+ ion might lead to a gain of function rather than to a complete loss of function.
Recruiting Rif1 and Rif2 to the telomere by fusion to other DNA binding domains also limits telomere elongation, indicating it is Rif1 and Rif2 function, rather than Rap1 per se, that limits telomere elongation (Levy and Blackburn 2004).
However, this has been interpreted as the result of a nonspecific change of domain geometry in FMIΔHRM leading to a total loss of FMI function rather than a specific loss of a putative HRM ligand binding activity.
As the residues important for eRF1 binding are also conserved in paralogues of eRF3, they may be important for a more universal EF1 structure or function rather than specific for eRF3 interactions with eRF1.
When completed, FLEX will emphasise function, rather than structure.
It executes a basic function, rather than a particular function.
However, dexamethasone may affect function rather than absolute numbers.
Firstly, the excess mortality rate is considered a smooth function rather than a step function.
Radiopharmaceuticals reflect physiologic and pathologic functions rather than anatomical abnormalities.
Forests were valued for their amenity and recreation functions rather than their economic function.
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CEO of Professional Science Editing for Scientists @ prosciediting.com