The study using the antibody against the Sp domain showed a new aggrecan-binding function of the Sp domain and its processing by human chondrocytes.
The structure of the human PITX2 homeodomain-DNA complex showed that the p.R113P mutation is indeed likely to affect the DNA-binding function of PITX3 [27].
In vitro binding activity assay showed that the hHP-1 had retained its binding function to a human HCC SMMC-7721 cell-line, without cross binding to other human normal tissues.
To evaluate the effects of low molecular weight heparin (LMWH) and heparin-binding epidermal growth factor (HB-EGF) on the biological function of human trophoblast in first trimester.
The function of human ASMTL is unknown.
In a series of previous studies, we successfully targeted coactivator binding pockets AF2 and binding function 3 (BF3) on the human androgen receptor (AR) and developed several potent AR inhibitors [ 38- 40].
Androgen, its receptor and binding proteins are known to affect several functions of human skin such as sebaceous gland growth, differentiation and growth of hair, epidermal barrier homeostasis and wound healing, and may play important roles in several skin-related disorders [ 71, 72].
Also, the significantly over-represented molecular functions of human calpain substrates are protein activity and various molecular binding, which can be dynamically regulated by cleavage (Supplementary Table S3).
About 30% of the nodes share the most popular GO term, protein binding function, for the main sub-graphs of the fly, worm, and human networks.
36, 37 Several groups have reported loss-of-function mutations in the ligand-binding domain of human PPARG, specifically in the adipose-specific PPARG-2.
