About 30% of the nodes share the most popular GO term, protein binding function, for the main sub-graphs of the fly, worm, and human networks.
The DBL-domain of Pf332 is more similar to the F2 than to the F1 region of the EBA-175 protein (Fig. 2); however, the absence of the WWXXXXXXXW sequence motif commonly found in other EBL family members suggests a distinct RBC-binding function for this domain.
Thus, the mSAA3 structure supports our biochemical data showing a retinol binding function for SAAs and explains how mSAA3 could bind retinol.
Thus, the thiol moiety may lead to effective CA inhibitors targeting isozyme I, whereas it is a less effective zinc-binding function for the design of CA II and CA IX inhibitors over the sulfonamide group.
It was possible to infer a ribosome binding function for HflX, due to ∼40 45% sequence homology between its G domain and that of Obg, DRG1 and Nog1, which bind ribosomal subunits and participate in its biogenesis.
Another possible binding site for RNA is in the ∼100-amino-acid RRM-like domains of Nup53p and its homolog Nup59p, although as yet no RNA-binding function for these has been assigned in vivo (Devos et al. 2006).
The authors identify two aromatic residues within the MC region that are conserved between eIF4E (W56 and W102) and human Ago2 (F470 and F505) and suggest an analogous cap-binding function for the identified residues.
Var genes are composed of multiple Duffy-binding-like (DBL) and cysteine-interdomain-rich (CIDR) domains that encode binding functions for specific endothelial receptors.
Since nucleic acids might also bind to the metal ions used for affinity purification, a nucleic acid-binding function for Sirt1 remains speculative.
This dye is generally considered a nucleotide analog, and thus the affinity of RKIP to the dye suggested a nucleotide-binding function for RKIP.
