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16, 17 Radiesse is not a mucopolysaccharide and therefore does not rely on water binding for its persisting clinical effect and it does not carry the risk of producing Tyndall effect (blue-gray discoloration) in the skin.
N-terminally truncated Notch 1 receptor construct (NEC), which does not require ligand binding for its activation and represents an immediate substrate of γ-secretase was a gift from Dr. R. Kopan [35].
Yeast Clp1 does not have ATP hydrolase activity but still requires ATP binding for its function.
The antibiotic geldanamycin (GA) inhibits HSP90's ATP binding for its proper interaction with client proteins.
The fungal defensin plectasin is another antimicrobial peptide that requires lipid II binding for its biological activity (Schneider et al., 2010).
The prospect of the novel concept of inhibiting collagen fibril formation by blocking collagen/collagen binding for its clinical utility is supported, in part, by earlier reports on the inhibition of intermolecular interactions.
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The textbook view of the activation process for JAK2 is that the 4-helix bundle cytokine possesses multiple binding sites for its receptor, and upon binding, these facilitate dimerization or multimerization of their cognate class 1 cytokine receptor.
Thereby, mRNA binding sites in TS overlap with the binding sites for its substrates, methylenetetrahydrofolate and dUMP and therefore, mRNA and substrate are in direct competition.
Previous studies on monocytic and colon cell lines suggest that plasmin pre-treatment can increase plasminogen binding, allowing the active enzyme to generate binding sites for its precursor.
Each gene features two binding sites for its repressor protein set so as to achieve cooperative binding, i.e. the binding affinity is larger when the gene is already bound to a single protein.
As capase-1 has no deep binding cavity for its ligands on its surface, the ligand-binding process occurs in the shallow crevice on the terminal surface of the receptor protein.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com