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These structures show detailed binding features of the inhibitors and highlight subtle changes in the orientation of side chains at different binding pockets in the active site in comparison with the active site of N- and C-domains of sACE.
The analysis of the binding features of the different chemosensors shows that the stoichiometry of the sensor Hg2+ complex depends on the concentration of the sensor and Hg2+ since it plays an important role in the type of response for Hg2+ ions.
This result reflected the selective binding features of the silkworm APNs.
Whatever the mechanism involved, the described binding features of the LukS-PV signal peptide to ECM components is not a general property of all other S. aureus signal peptides: the strains expressing LukF-PV signal peptide, TSST-1 signal peptide, LukD signal peptide and LukE signal peptide did not induce an enhanced adhesion phenotype.
The binding features of the L33 subunit are unknown, but the gene is only rarely lost (Wicke et al. 2011).
Each of the double substitutions also retains the ligand binding features of the single mutations it contains.
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The binding features of this mouse IgG2a antibody are described in detail.
Homology model of Leishmania SIR2 shed new light on the ligand binding features of this enzyme.
Another neighboring relationship in PubChem, known as "Similar Conformers", uses the notion of 3-D similarity (which considers the overall shape and macromolecule-binding features of the molecule) [6, 7] and is adept at finding related structures with different scaffolds.
Virtual screening and QSAR analysis were carried out to investigate the binding features of (2R, 3R, 4S -2-aminomethylpyrrolidine 3,4S -2-aminomethylpyrrolidined pyrrolidine derivatives to the α-mannosidase I and II enzymes.
Despite our successful characterization of the binding features of SRSF1 proteins, our future work will be applying RNAMotifModeler to studying specificities of other RNA binding proteins such as fox2, NOVA and EWS, for which high-throughput sequences are available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com