The antibodies against lipoproteins or LDL-binding factors were found in the blood of patients suffering from various vascular diseases as well as in healthy subjects [ 12].
The relative frequency of genes of a certain functions of all fish genes under positive Darwinian selection shows that more ATP binding proteins and transcription factors were found than could be expected based on the number of ATP binding proteins and transcription factors in general.
This term includes transcription factor binding and several transcription factors were found to be differentially expressed in this study.
Though it is not the focus of this study, the composition of the Cry1- and Cry2-associated protein complexes suggests that regulation of mRNA processing may be an important function for Cry1 and Cry2: a large number of RNA binding and RNA processing factors were found associated with Cry1 and Cry2.
Using the program Patch™ and entering a lower score boundary of 100% to detect only experimentally verified binding sites, only two putative binding sites for bZIP transcription factors were found in the cab11 promoter.
In the 5'-flanking sequence of the "2929-Prox1" binding sites for several transcription factors were found (i. e. cAMP-responsive Element Binding Protein (CREB) and Activator protein 4 (AP-4)).
No significant enrichment of consensus binding sites for other transcription factors were found in ChIP-seq peaks from the type IV-VIII response genes.
Additionally, putative binding sites for Nrf2 and XBP1 transcription factors were found at −32 bp and +14 bp, respectively (GenBank accession for TsTrx-1 gene is KM401604).
An overlap between CSSs and the binding sites of transcription factors was found to be enriched near transcription factor-encoding genes suggesting a role for CSSs in transcriptional regulation networks.
For example, Boyer et al. have experimentally identified the binding sites for several important transcription factors that affect stem cell identity, including OCT4, SOX2, and NANOG [ 25], and the binding sites of these three transcription factors are found proximal to many transcription factor genes, including themselves, and therefore may form self-regulatory network loops.
