Eph-ephrin binding within the same class is highly promiscuous and inter-class binding examples have also been reported [2], [3].
Many of them have a function in protein binding (for example, LCP1, TRAP1, ID4, TOB1, and CDH) and nucleic acid binding (for example, FBL, PIAS4, ELF3, EIF4G1, NBS1, and WHSC1L1).
Sometimes they are visited upon flesh and bones -- Chinese foot binding, for example, or the brass neck coils that the Padaung girls of Burma wear from age 6.
Mutation of any of these five residues influences receptor binding; for example, mutations to E148, which abolished binding to VD1, impaired the interaction with VEGFR-2 but enhanced binding to VEGFR-3.
However, it is becoming increasingly clear that certain TFs do require a particular set of histone TFs to access regulatory regions: MYC binding, for example, happens only in sites in which H3K4 and H3K79 methylations are abundant [25].
Such a binding, for example, could protect the backbone of replicators from hydrolysis or cleavage.
This C-terminal region likely is involved in nucleic acid binding, for example in template recognition.
The GlcNAc residues were neither necessary nor enhanced binding (for example, compare Man9GlcNac2, ligand 192, and Man9, ligand 312).
Alternatively, BRG1 may be required to establish the NDRs for MITF binding, for example after mitosis, or at specific stages of the cell cycle.
Outside-in signalling via high affinity β2-integrins occurs upon ligand binding, for example to endothelial ICAM-1 and depends on integrin clustering which increases integrin avidity.
