Sentence examples for binding events within a from inspiring English sources

Compared with previous tools, our new GSCA tool performs better by associating gene lists with ChIP-Seq peaks by calculating weighted associations between factors and genes based on the number of binding events within a gene locus.

Capitalizing on our recent observation that the BSI signal is proportional not only to the quantity of interacting species leading to conformation and hydration changes upon binding but also to the number of binding events within a molecule, we simply added the capture antibody to the assay to improve sensitivity.

Finally, we demonstrate that the digital genomic footprinting data also reveal potential binding events within coding regions.

Transcription factor binding events within lncRNAs were downloaded from ChIP-Base database [ 36], which aggregates high-throughput sequencing data taken from hundreds of ChIP-Seq experiments.

To further study the dynamic properties of EnCs, we used a time-counting analysis method (Cisse et al., 2013) to probe the temporal profiles of arrival times of stable binding events within individual clusters.

The 70 MammaPrint genes were analyzed for ERα binding events within 20 kb from the transcription start site (TSS), representing the most commonly detected window for ER-mediated gene regulation [ 20].

In brief, all TUs had evidence of Oct4, Nanog, and/or Sox2 binding events within 100 kb of the TU in one or both types of ChIP datasets (See Additional file 3).

2. We scanned the promoter sequences of the tissue-specific lncRNAs with PWMs corresponding to known transcription factors, downloaded from the JASPAR database [ 35]. 3. Independently of sequence, we calculated the statistical enrichment of measured transcription factor binding events within our lists of loci.

Ten out of 16 genes had an ERα binding event within 20,000 bp from the TSS (Fig.  3a), as exemplified for the LPCAT1 locus (Fig.  3a).

Using a publically available ChIP-seq dataset [ 22], the genome-wide chromatin-binding landscape of ERα in MCF7 cells was analyzed for the occurrence of an ERα binding event within 20,000 bp from the TSS of any of the MammaPrint genes.

Moreover, peak height can give a measure of the likelihood for the TFBS to be active in a given cellular context, as spurious binding events occurring within a fraction of the cells will give low ChIP-seq peaks.