Sentence examples for binding events such as from inspiring English sources

Electrical detection of biological binding events, such as protein protein interaction and DNA hybridization, has emerged as an alternative method to conventional colorimetric and fluorescence based methods.

This pattern results in a strand-dependent bimodality in tag density most evident in sequence-specific binding events, such as transcription factor-cis regulatory element binding (Figure 1).

Are the proposed "weak" binding events such as the Rio2-Crm1 interaction temperature-dependent?

Prenylation is frequently associated to reversible post-translational modifications or ligand binding events such as palmitoylation, phosphorylation or GTP-binding [5].

However, the binding affinity can be inferred indirectly, either by experimentally measuring frequency of TF binding events, such as chromatin immunoprecipitation (ChIP) [18], or by calculating the similarity of the DNA sequences with a known TF binding motif [19,20].

Furthermore, it suggests that other additional IKK2 oligomeric binding events, such as association through the V-shaped interface that was demonstrated to promote trans autophosphorylation, are of considerably low affinity.

Espinosa [ 35] and colleagues have proposed that p53 binding is not the rate-limiting step in promoter regulation, rather it is the post-binding events such as p53 post-translational modifications, chromatin modification and/or recruitment of other transcriptional regulatory proteins that would determine the activity of p53-bound promoters.

ChIP-on-chip studies are used to detect any protein-DNA interaction genome-wide, such as transcription factor binding, but also epigenetic events such as histone modifications, as long as a suitable antibody is available.

For example p53 is stabilized by releasing it from sequestration by MDM2 while p73-dependant transcription is abrogated (perhaps by tighter binding to MDM2) during events such as mitosis [ 67].

In addition we ask the question: What if data cannot be fit using the fitting functions incorporated in the data-analysis software that came with your ITC? Examples where such data might be generated include systems following non 1 n binding patterns and systems where binding is coupled to other events such as ligand dissociation.

However, we cannot rule out the possibility that the lack of PP1cγ isoform could alter PAR4 activation associated proximal signaling events such as binding of GTP to the G proteins that couple to PAR4.