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Dissecting the sequence of the binding events responsible for loading Meis/Pbx complexes onto chromatin, and the precise temporal order of such events, will require additional experiments.
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Although many cellular effects of oxidized phospholipids are mediated by receptors it is unlikely that specific receptor binding is the only primary event responsible for lipid activity.
This reduced binding of IPP in both Tyr204 mutants suggests involvement of this residue in the isomerisation event responsible for the formation of the IPP binding site, the orientation of the IPP substrate, or in the stabilization of the carbocation.
We conclude that active site ligand binding events themselves are responsible for conformational changes which promote enzyme-enzyme association of OTCase with arginase.
It is this preferential binding event that is responsible for enhanced MMP-9 secretion in cells when they express αvβ6.
For example, the top 200 bound motif-words are responsible for 4,006 binding events in the human genome; in fact, just 2,492 words (3.6% of the possible words) account for over half of the binding events in the human genome.
No binding event can occur for an already bound receptor.
The VEGF residues important for antibody binding and those responsible for receptor binding occupy a common region [ 52].
The international community has a legally binding agreement responsible for monitoring and responding to unsustainable levels of trade in wild animals and plants and to illegal wildlife trade.
To find RNA binding proteins responsible for modulating splicing during cancer progression, we can identify stage-dependent splicing pattern changes based on the ratio of alternative spliced isoforms and search for overrepresented nucleotide sequences near stage-associated splicing events.
It has recently been shown that unlike TF binding events with high TF occupancy levels (measured by ChIP signal), genomic regions with low TF occupancy levels are not responsible for patterned reporter gene expression in Drosophila (Fisher et al., 2012).
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