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Therefore, based on the random distribution model, the expected number of L1-embedded NANOG-binding sites located within LADs is estimated at 72, which is significantly less than the observed number of 104 binding events located within LADs (fig. 1).
The housekeeping genes and brain-specific genes showed similar association patterns with human-specific TF-binding sites, as measured by the number of binding events located within the boundaries of putative target gene-specific regulatory regions (table 2; fig. 4 and supplementary fig. S6, Supplementary Material online).
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First, on HsChr13, we identified a partially, though deeply, shared CTCF-binding event located within an ancient amniote SINE element (Hirakawa et al., 2009).
Since there is a possibility that those events occurred within the subducted Pacific plate, we next investigate ΔCFF for the target events located within the slab.
Fig. 6 As in Fig. 5 but for events located within 5 km from the surface trace of Atotsugawa fault.
AS events located within disordered regions can introduce variations that have a limited impact on protein folding [ 17].
In contrast, 15% of L1 retrotransposon-associated NANOG-binding events are located within truncated L1 sequences outside of the LAD boundaries (fig. 1).
A purine-rich consensus motif was identified in binding sites located within exon sequences but not introns.
Lectins are carbohydrate binding proteins located within protein bodies in the cells.
There are also 39 CgrA binding sites located within a protein coding sequence that have a gene located immediately downstream of the binding site (Fig. 3D).
This promoter function assay is the initial exploration of the roles for σ binding sites located within intragenic regions.
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