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The number of reads and AR binding events is shown in Appendix Table S4.
The naming structure for binding events is shown below: a BINDS b forming c a BINDS b forming c If more output molecules are present than inputs, the event is a dissociation event.
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For Oct4 and Nanog both unfiltered numbers and fractions after removal of bound regions located at <1 kb of a CTCF-binding event are shown.
The naming structure for dissociation events is shown below: c DISSOCIATES TO a AND b c DISSOCIATES TO a AND b Polymerization can be seen as a specialized form of a binding event.
Thus, we show that the ultimate limit of label-free detection of single molecule binding events is theoretically possible within the framework of 10.
These results show that the majority of ZNF217 binding sites are marked by active chromatin marks and that the predominant class of binding events is located at distal regulatory elements associated with H3K4me1 and H3K27ac.
However, the binding mechanism is different and the order of the binding events is reversed.
All NOS isoforms share a strikingly similar pterin binding pocket with comparable H4B binding affinities, and cofactor and substrate binding events have been shown to synergistically stabilize the NOS dimer.
The ideal, biologically sound definition of a functional binding event is that the TF has been shown to bind at the site on a gene's promoter, and this binding has been demonstrated experimentally to affect the level of transcription of the gene.
Recent research showed that cooperative binding events are evolutionary much stronger conserved (Göke et al., 2011; He et al., 2011; Kazemian et al., 2013) and show a greater impact on expression compared with individual binding events (Hemberg and Kreiman, 2011).
Further analysis showed that these binding events were virtually superimposable on the binding pattern of the full length LARS2 (Fig 3D), consistent with suppressive effect seen here and previously in yeast (Francisci et al, 2011).
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