Your English writing platform
Discover LudwigSuggestions(2)
Exact(1)
The limitation of narrow pH range could be alleviated through the incorporation of more enzyme per binding event, in an analogous approach to polymeric enzyme detection (Klonoski et al., 2010).
Similar(59)
Microarrays of proteins and peptides make it possible the screening of thousands of binding events in a parallel and high throughput fashion; therefore they are emerging as a powerful tool for proteomics and clinical assays.
Second, color-coding of proteins with QDs of different emission wave lengths offers the unique opportunity to monitor multiple binding events in a single experiment on a single bead.
One obvious elaboration is to model multiple binding events in a region.
Exploring protein-DNA binding events in a genome-wide manner is a key step in studying transcription regulation.
Likewise, multiple binding events in a region R r cause deviations from the unimodal density of the model.
The model also provides a goodness-of-fit test, to screen out spurious peaks and to infer multiple binding events in a region.
This label enables sensitive detection of less than 10 individual binding events in a single spot, down to fmol/L concentrations (Roche Diagnostics, Penzberg, Germany; proprietary data on file).
The NEXT-peak program also provides a goodness-of-fit test, automating screening of the spurious binding, and work is in progress to extend its model to locate multiple binding events in a region.
The method facilitates detection of weak binding events in a broad affinity range and could be used as a primary screening tool where ranking of binders in terms of affinity constants can be obtained by a single sample injection.
Thus, the captured images will allow for temporal and spatial monitoring of surface binding events in a label-free setup, allowing for adsorption and desorption kinetic measurements and highly sensitive biorecognition experiments.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com