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Target molecules and binding epitopes must be accessible to drug carriers, carriers must be free of harmful effects, and targeting should provide desirable sub-cellular addressing of the drug cargo.
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"Rules must be binding, violations must be punished, words must mean something".
The method has advantages relative to both immunoPCR (because no signal is produced by background binding) and the proximity ligation assay (PLA) (because only one epitope, rather than two epitopes, on a protein surface must be bound).
This implied that the binding epitope may be localized in hGH.
Consideration must be given to Vimentin specific binding epitopes otherwise a misdiagnosis of the patients' tumor samples may result.
"Rules must be binding.
"Stipulations must be binding," he wrote.
"Rules must be binding," he said.
Bearing in mind that the SAXS scattering curves for both signal peptide-containing and signal peptide-free TorAD complexes are identical, this must be taken as good evidence that the binding epitope for TorD on the mature portion of TorA must lie near the N-terminus and thus also near the second epitope within the signal peptide.
Such hnMAbs bearing distinct binding epitope have been rarely reported.
Coincidentally, the majority of the IgE-binding epitopes are also located in this region, suggesting that they may be protected from digestion by the monomer-monomer contacts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com