Sentence examples for binding epitopes derived from from inspiring English sources
The rational design of inhibitors using peptide binding epitopes derived from protein protein complexes represents an alternative approach.
A minimal linear binding epitope derived from the SKIP protein could be determined using a peptide array.
Given the relevance of integrin signaling for cellular homeostasis, we developed an injectable, bioactive peptide-based nanofiber matrix that presents an integrin-binding epitope derived from fibronectin, and evaluated its feasibility as a supportive artificial matrix for bone marrow-derived pro-angiogenic cells (BMPACs) used as a therapy in ischemic tissue repair.
Here we report a phase I/II clinical trial of subcutaneous peptide vaccination with two separate HLA-A2-binding peptide epitopes derived from WT1, together with a pan-DR binding peptide epitope (PADRE), in Montanide adjuvant.
In contrast to the epitopes derived from aggrecan and fibrillin, the MMP-3-derived epitope was also recognized in healthy controls.
With the aid of the TEPITOPE algorithm [31], our group has previously identified a set of 18 conserved CD4+ T-cell epitopes, derived from HIV-1 subtype B consensus whole proteome, capable of binding to multiple HLA-DR molecules [32].
While the epitopes derived from sequentially conserved regions may undergo mutations, it is worthwhile to explore the structurally conserved regions as a new dimension for epitope prediction.
The HIV antigens would need to be appended with or otherwise incorporate one or more T-helper epitopes derived from the glycoconjugate protein carrier to enable cognate memory T and B cell interactions.
Peptide vaccination for cancer immunotherapy requires identification of peptide epitopes derived from antigenic proteins associated with tumors.
Peptide vaccination for cancer immunotherapy requires identification of peptide epitopes derived from antigenic proteins associated with the tumor.
Epitope predictors are routinely tested on large sets of epitopes derived from various pathogens [20], [26].
