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Additionally, in another study, the HPV 16 E6 variant G131 (R10G) was demonstrated to alter a B*07 binding epitope such that it may influence immune recognition by cytotoxic T lymphocytes [ 59].
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The second possibility is that the TorD-binding site within the mature portion of TorA is very close to the signal peptide-binding epitope such that a single TorD protein could interact with both simultaneously.
Structural analysis suggests that S377-588-Fc conthenstablystably folded RBD structure, the full receptor-binding site, and major neutralizing epitopes, such that additional structures to this fragment introduce non-neutralizing epitopes and may also alter the tertiary structure of the RBD.
The batches of cellulose derivatives with heterogeneous dispersed substituents might carry more binding epitopes and/or such of a nature that can create stronger binding affecting the overall CBM-cellulose polymer interaction, reflected in an increased retardation in the AE gels.
Rationally designed protein protein interaction inhibitors mimic interfacial binding epitopes, specifically residues that contribute significantly to binding.
Conveniently, the epitope on gp120 for 17b overlaps with the CCR5 binding site, such that the displacement of antibody 17b from gp120 upon treatment with the sulfopeptide is indicative of the ability of the sulfopeptide to bind to gp120.
This may result in a continuum of binding specificities, such that some antibodies will have high avidity for epitopes on some PfAMA1 alleles and lower avidity for corresponding, albeit altered epitopes on other alleles.
Such hnMAbs bearing distinct binding epitope have been rarely reported.
Amino acid substitutions can be extra-epitopic, including those that affect epitope processing, or intra-epitopic, such as those that affect TAP binding, HLA binding, and TCR recognition.
This implied that the binding epitope may be localized in hGH.
The ligands were synthetic peptides that are derived from the smallest binding epitope 182DTNNN186.
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