This indicated that during hyphal induction H22 binding epitopes may be getting redistributed over different regions of the cell surface.
Different Bet v 1-isoforms have shown varying ability to initiate allergic responses 15, 16 and not all IgE-binding epitopes may be shared between the different isoforms, a fact that potentially could complicate diagnosis and specific immunotherapy.
The epitope may be sufficiently similar to the epitope of completely unrelated molecules, due to a combination of binding affinity and structural homology, as to result in high-affinity binding of the primary antibody to an unrelated and unintended molecule.
With respect to immunologic sources of non-specific reactions: The epitope may be sufficiently similar to the epitope of completely unrelated molecules, due to a combination of binding affinity and structural homology, as to result in high-affinity binding of the primary antibody to an unrelated and unintended molecule.
Recently, we designed an MBP epitope library consisting of fragments of this neuroantigen fused with Trx as a carrier protein and showed that the pattern of autoAbs binding to these epitopes may be regarded as a molecular signature of pathogenic B-cell response in MS (13).
The surface location of the OP-binding sites in albumin suggests that these epitopes may be available for reaction with antibodies.
It is conceivable then that certain epitopes may be masked and therefore unavailable for antibody binding, thus the importance of determining the nature of the circulating molecular forms of these analytes.
Alternatively, certain sets of epitopes may be needed to control the infection and thus, the more epitope motifs presented, the more likely individuals are to cover those epitopes.
These epitopes may be close to gB-NT.
The presence of multiple close allergen homologues across the fungal kingdom carrying epitope orthologues that are structurally indistinguishable from IgE binding epitopes may raise a considerable problem in diagnosis and classification of fungal allergy.
