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Most fucosylated sugars were not recognised, however, suggesting that CL-K1 contacts multiple monosaccharide moieties in each glycan and that the chemical environment of the binding epitope is important.
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It is known that the protein 3D structure underlying or surrounding an epitope is important in IgE binding but these regions are also highly conserved.
Identification of specific allergens and their IgE binding epitopes is an important step if low-allergen traits are developed.
Identifying B-cell epitopes is important for effective vaccine design.
Therefore, the accurate prediction of MHC binding peptides is important for understanding the mechanism of immune recognition and facilitating the process of epitope based vaccine design [ 2].
While the ability of binding to the β-Gal through the CBP (the Gal binding site) maintained well, the BV degenerates the H epitope/acetamido binding site that is important in the other GI NoVs and develops a Le epitope binding site differing from those of the other three GI NoVs.
Using multiple antibodies having different epitopes not only increases overall binding affinity, which is important for toxin extraction, but it also offers a unique opportunity to design a mixture of antibodies that bind a variety of epitopes, including regions that are conserved across the BoNT/A subtypes.
Epitope length is important in training the model and it is efficient to use variable length of epitopes.
Evaluation of the breadth and magnitude of cellular immune responses to epitope variants is important for HIV-1 vaccine assessment.
MHC-molecule-binding epitopes are responsible for triggering the immune response to antigens.
Coincidentally, the majority of the IgE-binding epitopes are also located in this region, suggesting that they may be protected from digestion by the monomer-monomer contacts.
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