Exact(42)
A compound would bind to proteins having similar binding environments; as well as proteins often interact with compounds of similar topology.
However, there are also many instances wherein a given ligand binds to the same or homologous protein in different binding environments.
Ligands representing important functional groups of natural organic matter facilitate Fe redox transformations and resulting binding environments.
The binding environments for substrate IP5 could be inferred by the two different binding sites for sulfate ion in CnIpk1.
By injection of large amount of PH3 during the synthesis, the effects of phosphorous incorporation on their microstructures and chemical binding environments were investigated.
Furthermore, Homopharma 3 and 4 also present different binding environments.
Similar(18)
We present X-ray absorption fine structure (XAFS) spectroscopy results investigating the binding environment of Cd (II), U VI) and Pb II) ions onto multi-layered graphene oxide (MLGO).
In conjunction with parallel X-ray diffraction, atomic force microscopy, and thermal-gravimetric analysis measurements, our experimental results show that the characteristic, quasi-twodimensional confinement of water between graphene-oxide sheets results in a binding environment remarkably similar to that in the bulk.
X-ray crystal structures have proven that a four heptad repeat scaffold contained in the three-stranded coiled coil (3SCC), called CoilSer (CS), provides an excellent motif for modeling a three Cys binding environment capable of chelating metals into geometries that resemble heavy metal sites in metalloregulatory systems.
Furthermore, the physical binding environment of the binding pocket was evaluated using SiteMap [43, 44].
Second, the ligand binding environment was analyzed in the absence of co-binding peptide with abacavir as the reference compound.
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