Sentence examples for binding engages from inspiring English sources

Ligand binding engages a pathway involving Dishevelled (Dvl) that inhibits GSK3, allowing β-catenin to accumulate in a hypophosphorylated form.

Our results establish a structural framework for understanding how P. vivax reticulocyte-binding protein engages its receptor and the molecular mechanism of inhibitory monoclonal antibodies, providing important information for the design of novel vaccine candidates.

If the structure were rigid, steric clashes would occur between actin monomers on one bridge and either the neighboring bridge or the DID-DD, depending on the binding site engaged (Figs. S5C and S5D).

This observation is sound, as IDPs frequently use motif binding to engage with their binding partners (Kragelj et al., 2015; Schneider et al., 2015; Tompa and Fuxreiter, 2008; Wright and Dyson, 2009).

This suggests a potentially pure kinetic effect of a diminished enzymatic activity in which, once below a threshold, GS, because of its poor binding, cannot engage V394L GCase and cannot be hydrolyzed, whereas GC can.

Assembly with other protein complexes may serve to activate these enzymes by providing additional factors that tip the balance toward better recognition of the substrate over free ubiquitin, such as the ubiquitin-binding UIM domain present in STAM, in whose case the UIM domain appears to provide additional strength to substrate binding by engaging with the proximal ubiquitin.

Upon ligand binding, TLRs engage the signaling adaptors MyD88 and TRIF, which initiate signaling cascades leading to the activation of the transcriptional factors NFκB and IRF3 that induce the production of inflammatory cytokines (IL-8, IL-10, pro-IL-1β, pro-IL18 and others) as well as a type I IFN response, respectively.

Most FH-binding bacteria engage FH through regions in FH spanned by domains 6 and 7 and/or 18 through 20.

Despite the extensive investigations in a number of laboratories particularly on neisserial Opa proteins, it remains unclear as to precisely how CEACAM-binding ligands engage with the receptors.

In contrast, SA157* recognizes a distinctive epitope and engages binding with hCXCL1 residues that are important for its interaction with glycosaminoglycans (GAGs; Fig. 5b).

CTCF is a DNA-binding protein that engages its 11 zinc fingers to bind to DNA at a large, information-rich consensus motif (Kim et al., 2007).