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Further structural characterization of eIF4E complexes revealed unique binding elements in different eIF4E binding partners that could be fused into a chimeric '4E-BP-like' mimic and dampen translational activity [ 98].
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Many studies have attempted to elucidate aspects such as the binding process, the promoter structure and its regulatory elements in different ways.
These two theses describe elements in different ways.
The variable presence and absence of these elements in different genes defines element patterns.
The binding elements are often occupied differently in different tissues, and these differences can be used to derive all type-specific sub-modules in silico.
miR-132 is encoded on human chromosome 17 and is transcribed by a transcription factor cAMP-response element binding protein (CREB) in different cell types [ 53].
In addition, recent evidence also suggests that EtOH can alter the DNA status [21] or glucocorticoid response element (GRE):DNA binding in different brain regions, including cortex and hippocampus, due to chromatin remodelling [22], raising the possibility that epigenetic mechanisms might underlie the EtOH-induced long-term changes in CRH and AVP gene expression.
Sequence comparisons led to the identification of key splicing regulatory elements, the so-called TRA/TRA-2 binding sites, conserved in different Drosophila species and in the female-specific exon of these dsx orthologous genes from non-Drosophilidae families.
The HIV-1 promoter has three Sp1 binding elements, and our analysis of the region in U3 revealed that the sequence readily adopts different G-quadruplex configurations within both its RNA and single stranded DNA forms.
It's putting different elements together in different combinations.
GTAG and CGTC elements come in different chromosomal arrangements.
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