Analysis of the DNA-PKcs promoter demonstrated ERE-binding elements located in close proximity to each other: an 'imperfect' palindromic ERE at position −184 and a half palindromic ERE at position −274 (Fig 2A).
A local translation slowdown upon ribosomal exit of SRP-binding elements in mRNAs containing these nonoptimal codon clusters is supported experimentally by ribosome profiling analyses in yeast.
CRE binding elements are also located in close proximity to the TATA box in the C. elegans mtl-2 gene and it has been hypothesized that they may be involved in replacing the role of MREs [31].
Another important difference between these genes is that SOX binding elements, often many of them, are in close proximity to SF-1 binding motifs in teleost cyp19a promoters [ 18, 25, 53, 54].
As in many bacterial species, Staphylococcal transcriptional regulators interfere with transcription initiation by binding on cis-acting elements located in close proximity of promoter.
People live in close contact with the elements.
However, T-box and Smad binding elements do not form part of the same motif, and although they appear in close proximity to each other they have inconsistent spacing, orientation and strand orientation relative to each other.
Characterization of the actin binding elements by mutational analysis assumes that actin binding occurs sequentially through the contribution of at least six flexible myosin loops, close-up views) that modulate, in a nucleotide-dependent manner, the interaction strength and coupling to actin [ 296, 310– 315] (see also [ 316]).
Ericsson, J., Jackson, S. M., Lee, B. C. & Edwards, P. A. Sterol regulatory binding element protein binds to cis element in the promoter of the farnesyl diphosphate gene.
