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Alternatively, the C-terminal tail may represent an independent binding element that recognizes a separate Sre1 surface.
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As such, 1,25(OH)2D exerts its effects by binding to a specific nuclear receptor (vitamin D receptor [VDR]), a ligand-dependent transcription factor that recognizes specific DNA sequences known as vitamin D response elements (DeLuca, 2004).
These variable regions of VP3 form the structural elements that recognize cell surface receptors.
ERF-4 is a DNA binding protein that recognizes a GCC-box element [31] and functions as a repressor of gene expression [32] [33].
The PPAR α, β, and γ isoforms share a highly conserved DNA binding domain that recognizes specific DNA sequences known as Peroxisome Proliferator Response Elements (PPREs) (11).
The WRKY domain is a 60 to 70 amino acid long DNA binding domain that recognizes the W-box (TTGACC/T); however, recent studies suggest this cis-element may be more degenerate and other components are involved for WRKY binding to DNA in response to a specific stimulus [ 30, 31].
The Src homology 2 (SH2) domain is the most prevalent protein binding module that recognizes phosphotyrosine.
24, 25 KLF8 is a relatively new member of this family and is a sequence-specific DNA-binding protein that recognizes CACCC-box element and repress active expression.
PPARs possess a central DNA-binding domain that recognizes a specific DNA sequence, the PPAR-response element (PPRE), in the promoter regions of their target genes.
Structurally, RXR contains a ligand binding domain (LBD) that recognizes various endogenous small lipophilic compounds such as 9- cis-retinoic acid (9cRA), and a DBD that recognizes a DNA sequence called RXR response elements (RE) [ 28].
This model predicts that functionally related genes are regulated posttranscriptionally as groups by specific mRNA binding proteins that recognize sequence elements in common among the mRNAs.
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