A number of putative transcription factor-binding elements were present in the promoter sequence, including STAT, ELK, p53, E2F, C/EBP, GATA, c-Myb, and AP-1.
For example, although E2F-binding elements are present in some histone gene promoters and the tumour suppressor Rb as a transcription repressor is involved in E2F-mediated transcriptional regulation, vertebrate histone genes are largely regulated by transcriptional activation rather than de-repression mechanisms (reviewed in [ 3]).
In particular, the evening element is present in the promoter region for TOC1, and the expression of this gene is repressed by the transcription factors CCA1 and LHY binding to the evening element (Alabadi et al., 2001).
The consensus GATA3 binding element is not present in the 5′-promoter region of human PTH, suggesting that the observed enhancing effect of GATA3 is caused by an indirect pathway, rather than by the direct binding of GATA3.
Our analysis revealed that a bipartite distribution of putative cis-acting elements is present between the two female-specific Aeadsx exons, with TRA-2-ISS, RBP1 binding sites and NvdsxRE almost exclusively present in the "strong" exon 5a and in the upstream intron, and putative Aedes TRA/TRA-2 binding sites and the PRE element present only in the "weak" exon 5b.
Also, a new putative DAF-16 binding element was identified.
The NF-Kappa B binding elements were exclusively present within the minimal promoter regions.
In the case of LTRs and LINEs, only ∼3.5% of the wt binding sites on LTR elements were present in the experiment with mt KAP1.
In all likelihood both elements are present in most settings".
These same two elements are present in great mobile apps.
