Sentence examples for binding efficacy to the from inspiring English sources

The most promising anticancer derivatives (5l, 5k, 5i and 5p) were further docked to study their binding efficacy to the active site of the cyclin-dependent kinase-8.

The functionality of polyclonal human IgG to the phosphocholine antigen was determined and showed that IgG encapsulation and release did not affect the antibody binding efficacy to the antigen.

The structural and functional studies suggest that the variant allele (Asp148Glu) was localized in APE1 binding region; hence the mutation may play a significant role by altering its binding efficacy to its substrate and thus affecting the structural and functional properties of protein.

Among a series of NAP derivatives synthesized, compounds 6 (NMP) and 9 (NGP) maintained comparable binding affinity, selectivity and efficacy to the lead compound.

These include (i) break — SNP completely disrupts the binding of miRNA to the MRE, (ii) decrease — SNP reduces the binding efficacy of the miRNA to the MRE, (iii) enhance — SNP increases the binding affinity of the miRNA to the MRE and (iv) create — SNP creates new MREs for miRNAs.

To study the binding efficacy of capadenoson to A1 adenosine receptors, we measured ligand dependent G protein activation by binding of [35S]GTPγS to membranes of human brain cortex.

Therefore, the covalent conjugation will lead to a decreased binding efficacy of the antibodies.

Putative mRNA targets were selected based on a high sequence complementarity and binding efficacy between the target gene and the deregulated miRNA, as well as a known relevance to either Ig production and/or B lineage differentiation.

Such findings serve to emphasise that very subtle alterations in amino acid residues can have major implications on drug binding efficacy and highlight the importance of understanding the structural basis of drug binding, which is not always apparent from analysis of DNA sequences.

We quantify the binding efficacy of the ligand-coated-particle in terms of its multivalency, binding free-energy landscape, and the losses in the configurational entropies.

Therefore, further studies are needed in order to improve the serum stability of CaIX-P1, optimize its binding efficacy and lead to generation of peptide-based ligands, which can be used for targeting human carbonic anhydrase IX and tumor hypoxia.