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As of October 2011, member states were in arrears to the UN regular budget for their legally binding dues for a total of $867 million.
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Legally binding dues assessments for the regular UN budget in 2011 were $2.4 billion, which represented a slight increase from 2010.
One of the key differences between the two Smads is the ability of Smad-3 to bind directly to DNA through its MH1 domain while Smad-2 requires Smad-4 for DNA binding due to a 30 amino-acid insert in this domain [22].
According to the FDA guidance [ 7], a potential alteration in protein binding due to impaired renal function for drugs with an extent of binding less than 80%% would likely lead to a relatively minor change in the unbound fraction of circulating drug.
The lack of a major conformational change upon binding suggests that the structure of SFTI-1 is rigid and already pre-organized for maximal binding due to minimization of entropic losses compared to a more flexible ligand.
The fact that Mad and Arm interact with different domain of dTcf independently would not exclude the possibility of competition for binding, due to conformational changes upon protein/protein interaction.
Further, endothelial targets that appear in the pathological sites may require more time for binding due to inefficient perfusion.
The N-terminus has a high affinity for chromatin binding due to which the autoantigen remains tightly associated with chromatin during entire cell cycle [7, 14, 15, 16].
These features indicate that the 3'-end of the cleaved DNA (-1 position) is a potential site for quinolone binding due to likely distortion of the double-stranded DNA at the cleavage point, as supported by clerocidin labeling experiments [36].
Transition metal solutes show drag for attractive solute-vacancy binding as well as for repulsive binding, due to faster reorientation rates of the vacancy around the solute compared to dissociation rates.
This decrease in sorption capacity at high biomass concentration would be a consequence of lesser availability of cell surface for metal binding due to cell aggregation [31].
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CEO of Professional Science Editing for Scientists @ prosciediting.com