PKA is better understood than PKG structures of PKA in the cAMP bound and holoenzyme forms showed how, without cAMP, the cyclic-nucleotide binding (CNB) domains in the regulatory (R) subunit of PKA bind and inhibit the catalytic (C) subunit, and subsequently, how cAMP binding drives conformational change in the R subunit to release the C subunit, allowing phosphorylation.
Morrison, E. A. et al. DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.
This would prove that substrate binding drives pumping, the model we prefer, as pumping can occur without hydrolysis.
Julien, E., Bordeaux, M. C., Garel, A. & Couble, P. Fork head alternative binding drives stage-specific gene expression in the silk gland of Bombyx mori.
These studies suggest an alternative model of CRL dynamicity where the abundance of adaptor modules, rather than cycles of neddylation and CAND1 binding, drives CRL network organization.
Ultimately, a rational structure-based design strategy was successful for the identification of Siah inhibitors in which peptide binding drives specific covalent bond formation with the target.
On the basis of these findings, a commonly asked question is how substrate binding drives this transport.
The first step is the membrane binding, driven by the electrostatic interactions between the positive peptide charges and the negative charges located in the phospholipid polar heads [22].
Several studies suggest that high-affinity antigen binding drives naïve B cells to differentiate into short-lived, isotype-switched plasma cells (PCs) within the extra-follicular region which contributes to the initial control of infections.
According to our calculations, Mg2+-independent adenine binding drives the nucleotide association with PKA.
