Interestingly, the two zebrafish genes whose expression increased upon Ras activation, contain regions that are highly homologous to riboflavin synthase-like and NAD-binding domains, which have been directly involved in the enzymatic activity of human Nox4.
Some of these neighborhoods also encoded a protein with a VP1/RAV DNA-binding domain, which has also been found in association with REs like EcoRII [ 10]. 3) The third type of operon encoded a distinct SFII helicase with a conserved C-terminal globular α+β domain possessing a DThhQXuRhFG motif (h: hydrophobic, u: tiny).
The interaction between the EF hand domain and the IQ ligand, while also described as a domain-motif interaction, differed in several ways from other domain-motif interactions studied here: it involved the simultaneous binding of at least two domains, which have different orientations towards the peptide.
Although DIPA contains a basic region-leucine zipper DNA binding and dimerization domain, which has similarities to FRA family members [ 47], DIPA has never been reported to interact with the AP-1 complex, EGR4 or FHL2.
Members of the NLR family share common structural and functional similarities with the TLRs, which include a carboxyl-terminal LRR; a central nucleotide binding domain (NACHT) domain, which has intrinsic ATPase activity; and an amino-terminal protein-protein interaction domain, which contains either a caspase activation and recruitment (CARD) domain or a baculovirus inhibitory repeat domain [ 12].
All SIRT proteins contain a conserved NAD+-binding site and catalytic domain, which has been termed the core domain (31).
All putative flower MMP genes, with the exception of Glyma01g04350, had an E (glutamate) to Q (glutamine) residue substitution in the zinc-binding motif of the catalytic domain, which has been identified in other legume species [ 51].
WRN encodes a member of the RecQ family of helicases [10] but also contains a 'helicase, RNaseD, C-terminal conserved' (HRDC) domain, which has DNA-binding activity [11,12], and 3′ 5′ exonuclease activity due to a motif located near the N terminal of the protein [13].
Tropomyosin receptor kinase B (TrkB) is a transmembrane receptor with an intracellular tyrosine kinase domain, which has a high binding affinity for BDNF.
It is well known that PR5 proteins are defense proteins, have membrane binding domains which affect the permeability, thus impeding the growth of invading microbes (Grenier et al., 1999).
