This is supported by several reports where the absence of the catenin binding domain was shown to abolish the adhesive activity of E-cadherin [39], [52].
Structures of the most common RNA-binding domains are shown in Figure 1 and described below.
Similarly, acetylation of lysine 120 in the p53 DNA-binding domain was shown to stimulate transactivation of PUMA, but not p21 (Sykes et al, 2006; Tang et al, 2006).
MALT1 dimerization hybrids with a gyrase B or helix loop helix domain, as well as multiple FKBP (FK506-binding protein) domains were shown to exhibit activity and NF-κB activation in cell transfection experiments [ 6, 9, 34].
Oligomerization and polyubiquitin (poly-Ub) binding, mediated through the regulatory CC2-LZ domain, were shown to be key features governing NEMO function, but the relationship between these two activities remains unclear.
In rice, RPBF (rice prolamin box binding factor) which contains a DOF domain, was shown to be involved in the regulation of endosperm expressed genes [ 56].
The inserted sub-domain is shown to be involved in substrate binding and dimerization.
Attempts at localising ChR2 to the AIS using only the 9 aa [84] or 27 aa [86] ankyrinG binding domains were less successful (data not shown), suggesting that ChR2, like VGSCs, requires the II-III loop membrane removal sequence [87] and/or CK2 phosphorylation sites [90] for complete AIS targeting.
In A. aegypti, AeIMUC1, a mucin that encodes putative chitin-binding domains was recently shown to bind heme [ 21].
Mutation of the valine to alanine, or phenylalanine to alanine, within the (K/R)/(V/I)/XF PP1 binding domain, has been shown to affect the binding of PP1 with other interacting proteins [ 22].
