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TFs are special types of proteins that have DNA binding domains that can bind at specific sites of DNA defined by particular sequences of certain length.
RPA is composed of six oligonucleotide/oligosaccharide binding (OB) domains that bind ssDNA and/or participate in specific protein−protein interactions (21).
Several cell-based assays have also been designed using effector-binding domains that bind to the GTP-bound form of certain GTPase.
A defining feature of transcription factors is that they contain one or more sequence-specific DNA-binding domains that bind to the promoter and/or enhancer regions of target genes to regulate gene expression [ 1, 2].
Fibrinogen binds to a wide variety of nanomaterials because it has several different binding domains that accommodate different nanomaterials [19].
The larger isoform has an extended amino terminus that encodes Z-DNA-binding domains that can bind to dsRNA (Oh et al, 2002; Koeris et al, 2005; Placido et al, 2007).
ERT2 is a mutated form of the human estrogen receptor-α ligand binding domain that does not bind estrogen agonists but binds the partial agonist antagonist 4-hydroxytamoxifen (4-OHT) [ 19].
Both encode a repressor protein (gp71 and gp69 respectively) containing a predicted helix-turn-helix (HTH) DNA binding domain that binds to 13 bp asymmetric DNA sites.
Therefore, the HYB is constituted by four zinc-binding domains that participate to bind pTyr residues surrounded by acidic amino acids [ 50].
Recent studies have demonstrated that NEMO contains an ubiquitin binding domain that is able to bind to K63-linked polyubiquitin chains on RIP1 12, 12. Another prediction of the model that NEMO restrains RIP1 is that mutations in NEMO that compromise its binding to ubiquitinated RIP1 will also lead to enhanced sensitivity to apoptosis in a NF-κB-independent manner.
The variant human PPARA-tr transcript lacks the entire exon 6 due to alternative splicing, leading to a premature stop codon and the generation of a truncated protein (PPARα-tr) with deficient ligand binding domain that is unable to bind to peroxisome proliferator-responsive DNA elements (PPRE) (Fig. 1).
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