Unlike Cox18, Oxa1 has a long C-terminal extension containing a ribosome binding domain capable of interacting with the mitochondrial protein translation machinery.
Once gp120 is bound with the CD4 protein, the envelope complex undergoes a structural change, exposing the chemokine binding domains of gp120 and allowing them to interact with the target chemokine receptor.
A rational design of effective chemically modified siRNAs must consider the 3′ and 5′ termini of siRNAs as critical determinants for the silencing activity because these regions interact with the binding domains of hAgo 2, that is, the signature component of the RNAi machinery.
This interaction might trigger conformational changes in MP that allows the RNA binding domain of MP to interact with RNA.
Instead, the RNA-binding domains of TERT interact with TR to facilitate the elongation of the telomere repeats via the catalytic activity of the RT domain [11], [12], [13], [14], [15].
To map the binding domain of CFH that interacts with HcpA, recombinant deletion constructs of CFH representing SCRs 8-10, SCRs 15-10, SCRs 19-20, and SCRs 1-7/FHL-1 wemployedoyemployed
The protein phosphatase 2A (PP2A) binding domain of MCV sT interacts with PP2A, as also seen with SV40 sT, but mutation of the PP2A binding domain does not impair the oncogenicity of MCV sT.
The substrate binding domain of Hsp70 recognizes and interacts with sequences of hydrophobic amino acid residues of newly synthesized proteins that emerge from the ribosomes.
In one such structure, it was shown that the NEMO binding domain of IKKβ (residues 701 745) interacts with the region of NEMO extending from approximately residues 44 111, within the helix 1 domain.
In this study, the gelatin binding domain of fibronectin was shown to interact with LigBCen2R (KD = 1.91±0.40 µM).
