Gu et al. recently generated p53 mutant mice with three lysine to arginine mutations at three positions in the DNA binding domain important for regulation of p53 by post-translational acetylation.
The HES1 protein contains both DNA-binding and protein-protein interaction domains important for its function as a transcriptional regulator (including negative regulation of its own transcription) [ 9, 11, 12].
This domain is likely to be a sequence-specific RNA-binding domain important for regulating mRNA translation (Loedige et al. 2013, 2014).
Actin was monitored in these embryos by following the distribution of GFP-tagged moesin, an Ezrin-radixin-moesin (ERM) family member with a conserved actin-binding domain important for orchestrating actin redistribution to rings in the embryo syncytial cycle (Kiehart et al., 2000).
ESR1 is an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.
ESR1 encodes an estrogen receptor (ERα), a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription [ 32].
ESR1 encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription [ 25].
Val-145 resides in the N-terminal region of the helix D (Figure 7A), containing domains important for binding site III of leptin.
Apart from these domains, important for DNA binding and dimerization with HIF-1β, respectively, a central oxygen-dependent degradation domain and two transactivation domains, the N-terminal activation domain (NAD) and C-terminal activation domain (CAD), are recognized in their structures [4].
These include residues in the ROC domain important for GTPase binding and residues in both the ROC and COR domains important for domain interactions and GTPase activity (see Legend to Figure 4).
