For example, DNA binding domains are frequently derived from class II DNA binding domains [reviewed in [ 178]].
A, link protein-binding domain; B and B′, hyaluronan-binding domains for G1 and homology domains for G2; E, epidermal growth factor-like domains; L, lectin-like domain; C, complement regulatory protein-like domain.
Feschotte (2008) in particular extols the possibility of co-optation of transposase (TPase) genes, which often encode DNA-binding domains and various chromatin modifying effects ripe for repurposing into host functions (and ripe for confusion with host functional elements by approaches like ENCOD Es).
Typically, PAS domains are covalently linked to and regulate the activities of various effector domains, including enzymes, transcription factors/DNA-binding domains, ion channels, and chemotaxis proteins.
Ryanodine receptors (RyRs) are calcium release channels mainly located on the endo(sarco plasmic reticulum, with a majority of their mass (consisting of the regulatory domain with multiple binding sites for various ligands) found in the cytosol, whilst the relatively small transmembrane region forms a cation selective ion channel (Samso et al., 2005).
However, since megalin's binding domains facilitate the binding of various endogenous and exogenous peptides, it is also possible that some or all of these sequences are not actually involved in the binding of intact albumin to megalin; for example because they may not be exposed at the surface of the albumin molecule.
PIP3 acts as a binding site for various intracellular enzymes that contain a pleckstrin homology (PH) domain, such as the serine/threonine kinases phosphoinositide-dependent kinase 1 (PDK1) and protein kinase B (PKB).
It has several binding sites on each fibrinogen-like domain: an outer binding pocket, also present in H-and M-ficolins, together with three unique sites, which form a continuous binding surface for various acetylated and neutral carbohydrate ligands.
