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The gp160 spike contains binding domains for both CD4 and chemokine receptors.
In addition, DHCR24 contains conserved binding domains for both p53 and Mdm2, required for mediating cellular responses to oncogenic and oxidative stress [ 3].
The N-terminal heme binding domains for both types of cyts b5 have very similar structural folds consisting of six α-helices and four β-strands.
The key residues are Gly9, Ser10, Ile11, Leu12, Lys13, Lys14, and Val15 which were the major binding domains for both Ki-67 and p27 to the CDK1 shown in red ribbon.
However, the Dia-N′ construct, in which the binding domains for both cues are intact, displayed apical enrichment values of ≈7, clearly indicative of synergy between Rho1 and PI 4,5 P2 in promoting Dia apical localization.
Some lipid transport may also occur via non-vesicular routes, as contact sites can often be seen between the trans-Golgi and ER (see, for example, Figure 1a), and some sterol and ceramide transport proteins have binding domains for both organelles.
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Using these deletion constructs, we were able to tease out the binding domain for both ERα and ERβ within the βγ-subunit-binding domain.
Christiansen, C. Investigation of starch binding domains for improvement of starch degradation.
Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators.
FN has several binding domains for interaction partners in the ECM like collagen I (dark blue) or growth factors (orange).
These experiments reveal distinct binding domains for the Rab9 GTPase and MPR cytoplasmic domains in the cargo selection protein TIP47.
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