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In addition, specific cell wall binding domains derived from endolysins are exploited for the development of diagnostics.
The protein is lenercept, an immunoadhesin comprising the Fc domain of human IgG1 and two tumor necrosis factor (TNF) binding domains derived from the extracellular portion of the TNFR1 p55).
In this study, we made novel fusion proteins PAxPG with a flexible (DDAKK n linker between the two Ig binding domains derived from Staphylococcus protein A and Streptococcus protein G.
The active domain of human AMP cathelicidin, LL37, and two chimeric peptides containing LL37 fused to collagen binding domains (derived from collagenase – cCBD-LL37 or fibronectin – fCBD-LL37) were synthesized and adsorbed to PURACOL® type I collagen scaffolds.
Similar(56)
The PepX database was used to determine a list of known peptide-binding domains derived from protein fragments or protein domains in complex with peptides [ 43].
A heterodimeric antibody with one binding domain derived from the C225 antibody and one binding domain derived from the humanized 425 (hu425) antibody was built on the strand-exchange engineered domain (SEED) scaffold.
PERV-A14/220 contains the receptor binding domain derived from PERV-A and therefore uses PERV-A receptors for cell entry [38], [41].
211c Met-lead 1.59 consists of an ECFP with the last 11 amino acids deleted (ECFPΔC11) and cp173Venus FRET pair connected by a Pb2+ binding domain derived from the bacterial metalloregulatory protein PbrR.
These results suggest that COOH- and NH2-SAMs allow for both cell adhesion and cell spreading because of the high density of cell-binding domains derived from adsorbed Vn.
Here, we composed the largest set of PDZ domains derived from human, mouse, fly and worm proteomes and defined binding models for PDZ domain families to improve the domain coverage and prediction specificity.
The designed fusion protein also had a cell-adhesive RGD sequence and a collagen-binding domain derived from fibronectin.
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