Sentence examples for binding domains can be from inspiring English sources

The coupled CRIB and PDZ architecture of Par-6 reveals how simple binding domains can be combined to yield complex regulation.

This procedure results in a library containing phages displaying polypeptides of varying sizes and thus, from such a library, also proteins containing large binding domains can be isolated.

These mutations of the p53 DNA binding domain can be divided into two groups [ 24].

The targets of the DNA binding domain can be identified using a technique called ChIP-seq, in which chromatin immunoprecipitation (ChIP) of a transcription factor is coupled to sequencing (-seq) of its target DNA.

However acetylation of p53 at K120 within the DNA binding domain can be catalysed by TIP60 in response to DNA damage, and has been implicated in activation of pro-apoptotic pathways both dependent on and independent of transcription [ 25- 27].

Since we are using a nucleosomal template containing both LexA and Gal4 binding sites, chimeric proteins containing a LexA or Gal4 DNA binding domain can be used and fused to distinct peptides or protein domains that are known to interact with a particular chromatin modifying enzyme.

Zinc finger DNA-binding domains can be combined to create new proteins of desired DNA-binding specificity.

In this respect, zinc finger protein DNA-binding domains can be engineered to target virtually any gene.

Moreover, engineered CBMs fused with antibody-binding domains can be used as biosensors for sensing pathogens, biomarkers and environmental pollutants (Hussack et al. 2009).

All isoforms contain exons 1 5 and the terminal exon, exon 8. Exons 6 and 7, which encode heparin-binding domains, can be included or excluded.

For example, the TALE DNA-binding domains can be combined with either a catalytic DNA endonuclease domain, such as FokI, to allow gene editing, or a transcription factor (TF) domain for gene activation.