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These IP assays consistently demonstrated that BRAFV600E binds to the C-terminal region of MST1 (Fig. 4C), which contains of regulatory binding domain with the Sav/RASSF1/Hpo (SARAH) domain of RASSF1A [41], [42], [42].
Most surprisingly, only 7 out of 23 BORIS isoforms encoded a full-length 11 ZF DNA binding domain, with the number of ZF in the other isoforms ranging from 1 to 10 (File S1, Table S3).
HMGNs share a common N-terminal nucleosome binding domain with the conserved basic octapeptide sequence, RRSARLSA.
Tcf15 shares an almost identical DNA binding domain with the closely related bHLH transcription factor Scleraxis (Scx) (Burgess et al., 1995).
According to their predicted structures, sixteen of the BdDof genes have no introns whereas ten of them contain one intron, generally placed up-stream of the DNA binding domain, with the exception of BdDof7 with an intron down-stream of it, and of BdDof18, which has two introns.
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Each PRR comprises two putative overlapping Src homology 3 (SH3) binding domains with the consensus PxxP motif that is reported to mediate the binding to a large number of eukaryotic signaling proteins containing the well-characterized SH3 domain [ 109].
MSCs have been shown to possess a strong attachment to fibrin by way of small binding domains with the cell membrane, something not found with other cell types [ 50].
We developed a multi-domain synthetic peptide, LA2, which combines IKVAV sequences with a heparin-binding domain with the goal of improving cell attachment to otherwise non-adherent substrates.
Moreover, our determined crystal structure of the bigelovin-activated RXRα ligand-binding domain with the coactivator human steroid receptor coactivator-1 peptide revealed that bigelovin adopted a distinct binding mode.
ABC proteins have in common that they all contain a nucleotide-binding domain with the characteristic Walker A and Walker B motifs.
All of the nuclear receptor protein sequences contain a highly homologous DNA-binding domain and a less conserved ligand-binding domain with the exception of the NR0A group.
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