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One encoded the predicted full length leptin binding domain while the other cDNAs were shorter as a consequence of different deletions in exon 9, and one had a further deletion in exon 10.
The MH1 domain contains the DNA binding domain, while the MH2 domain is involved in protein-protein interactions and transcriptional activation (reviewed in [38]).
While BIM is considered an ATP mimetic, we note that conventional and novel PKCs, that are inhibited by BIM, all have a cysteine residue within the ATP binding domain, while the atypical isoforms of PKC (iota and zeta), which are resistant to BIM, lack this cysteine.
Similar(56)
The β-strands sweep toward the FMN binding domains, while the α-helices run in the opposite direction around the periphery of the protein.
We may ask whether the d and e isoforms could be functional as they both contain the ribonuclease III domain, the dsRNA binding domain while only the d isoform contains a PAZ domain.
Although cytoplasmic binding partners have not been identified for prominin-1, the C-terminal tail of SV3-5 resembles a class II PDZ-binding domain, while the C-terminal tail of SV1-2 and SV7-8 harbors characteristics of a class I PDZ-binding domain [18].
A3A, A3C, and A3H present one copy of the zinc-binding domain, while the remaining harbor two copies; the N- and C-terminal domains are named CD1 and CD2, respectively.
51 LHCGR has eleven exons: the first ten exons code for the extracellular ligand binding domain, while exon 11 codes for the 7-transmembrane and intracellular domains of the receptor.
It is interesting to note that the GT-B family had shown remarkable structural conservation in the C-terminal sugar donor binding domain while variations were found in the N-terminal regions as well as in the helices, loops, and active site which have evolved naturally to accept diverse molecules [ 38].
In RORB1, nine amino acids precede the first cysteine of the DNA binding domain, while in RORB2 there are twenty residues before this cysteine.
itprug3 is a hypomorph in which the single point mutation lies in the N-terminal ligand binding domain while itprsv35 is a null allele with a stop codon in the modulatory domain [4].
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