Thus, these two isoforms contain identical extracellular and transmembrane domains, which predicts identical adenovirus binding and serotype preference.
Calmodulin dependent protein kinase I (299 320) binding domain, which is a putative CaM-binding region, was obtained from AnaSpec.
TFs have different DNA-binding domains, which form the basis for their classification into different families, and up to 5% of genes in vertebrate genomes are predicted to be TFs.
This is consistent with bioinformatic analysis of the amino acid sequence, which predicts a chloroplast transit peptide, and a well-conserved C-terminal carbohydrate-binding domain (present study, also [ 5]).
This gene encodes the nucleolar protein dyskerin which has a dual role as a pseudouridine synthase via its TruB domain, homologous to that of pseudouridine synthases in bacterial TruB proteins, yeast Pus4p and the yeast dyskerin homologue Cb5fp [28], and as an RNA-binding protein via its PUA domain which is predicted to play a role in binding H/ACA and telomerase RNAs [29,30].
fru P1 transcripts are alternatively spliced at their 3′ ends into one of five exons that encode different zinc finger domains, which are predicted DNA binding domains (DBD; named A-E) [ 6, 19, 21, 22].
These isoforms vary in their carboxy-terminal zinc finger domains, which are predicted to facilitate DNA binding.
Qualitatively, this formalism, which assumed structural uncoupling between individual binding domains, predicted the effect of varying valency on the concentration threshold for phase separation [ 46].
Additional domains, such as regulatory or binding domains, modify these predicted functions encoded in the TSPs.
All three pneumoccocal sialidases possess a carbohydrate-binding domain that is predicted to bind sialic acid.
